1.Innovative biotherapeutic technologies for the treatment of malignant tumors.
— Cloning of self-activated antitumor lymphocytes (adaptive immunotherapy).
Medical technology is based on the ability to clone (multiply and obtain copies) immune cells and the phenomenon of activation of these cells of cancer patients outside the body to fight cancer. From the vein, the host’s own blood is extracted, the cells of the immune system are selected from it, which can best resist cancer cells. These cells are delivered to the laboratory, cloned and activated inside special bioreactor-incubators. Cultivated biologically by billions of killer cells by injection «return» to the patient’s body, immediately attacking the tumor. The technology has received international recognition and is called adaptive immunotherapy. Under certain conditions, the use of such treatment allows the tumor to be destroyed by a biological method that is gentle to the patient and to save patients in the most severe and neglected cases.
— Bioembriotherapy (disruption of the immunorefense of a malignant tumor).
One of the first clinically proven techniques of cancer biotherapy (since 1976). It is based on previous observations of «folk» medicine. The technology is based on the introduction of bioprocessed normal placenta trophoblast cells that have similar properties to malignant tumors. Subcutaneous administration of such a vaccine effectively destroys the mechanisms of tumor protection (its immunorefense) from the host’s immunity of the tumor. By losing protection, a malignant tumor becomes visible to the immune cells and is subjected to a powerful attack. If the patient’s body is not exhausted by illness, chemotherapy and radiation, then complete regression (disappearance) of the malignant tumor and its metastases is observed. The effect of such treatment persists for decades.
— Immunotherapy with vaccines based on lysates of autologous tumors.
One of the most active antitumor vaccines, activating their own protective forces. To produce it, the cancer tissues of the patient are used. That is, the vaccine is created on the basis of individual tumor antigens and is prepared for only one particular patient. A tumor under sterile conditions is taken directly during a surgical operation, within a day the material is delivered to the laboratory, where the vaccine is prepared. In immunized patients, a significant beneficial effect is guaranteed.
— Chimerization of the immune system by active antitumor cells (graft versus tumor).
The most promising newest cellular technology. With this method, there is a hope for a radical cure of patients with malignant tumors at any stage of the process and regardless of the general condition of the recipient (the patient — the host of the tumor). The basis is the method of chimerization of the cellular pool providing immunity, a new, artificially created, activated state of the immune system, when antitumor immunity is provided by two or more genetically different types of immune cells. Chimerization uses stem cells from donors with superhigh potential in the fight against malignant tumors.
2.Cellular transplantology — innovation in medicine.
— Rehabilitation after brain damage through the use of stem cells.
Transplantation of own stem cells is the most effective and the only widely clinically proven method of treatment and rehabilitation of patients with consequences of trauma or cerebrovascular accident. The use of own stem cells after a stroke or a brain injury can minimize the consequences of brain damage, compensating for the functional defect of the central nervous system. The newest technology is based on the ability of its own stem cells to systemically enter the vascular bed to penetrate into the area of brain damage, activating the recovery processes and preventing the death of nerve cells.
— Animation (cloning) of hair — treatment of alopecia.
For the first time in Russia, the cellular technology of hair multiplication (cloning) has been reproduced in clinical practice and improved, the measures to take a biopsy of scalp hair follicles, to isolate, cultivate specific cells and the technique of cell material transplantation have been perfected. Transplantation of own cells responsible for hair growth leads to an increase in the total number of hairs on the skin of the scalp.
— Induction of vascular growth, growth and enlargement of the penis.
— Revitalization — decrease in biological age against the background of stem cell transplantation.
The dramatic process of aging is a sequence of unrelenting, long-term structural degradation changes in the body, accompanied by a gradual decrease in the functional activity of all organs and systems. According to American researchers, the age at which a person can remain absolutely healthy is 44 years for women (with an average life expectancy of 78.8 years) and 40 years for men (with an average life expectancy of 72.6 years). That is, in the last 32-35 years, every average person suffers from the physical infirmity of a fading life. The viability of a 90-year-old man is 500 times lower than that of a young man. The renewal of the cellular composition of the body depends on the stock of stem cells, which is the most important condition for maintaining health and longevity. The number of stem cells in the body is the only indicator that decreases thousands of times with increasing human age. Reducing the biological age of an aging person by transplanting stem cells that initiate the process of gradual tissue renewal is called revitalization. In revitalization, the goal is to increase the functional activity of tissues to prolong the period of socially and personally-interested life of people. At the heart of medical technology is the ability to clone outside the human body within the bioreactor, where the conditions of intrauterine development of the fetus are reconstructed, a significant number of own stem cells that are distributed throughout the system through intravenous administration and maintain physiological regeneration.
— Transplantation of autologous and allogeneic stem cells — a breakthrough in the treatment of progressive chronic diseases.
Recovering a person after a trauma or disease occurs with the direct participation of his own stem cells. With age, the number of these progenitor cells decreases dramatically, the level of health and quality of life decreases, and in many diseases the stem cells exit from the bone marrow to the bloodstream (in norm this is a necessary mechanism for maintaining health). Often the patient’s body does not have reserves and does not receive a push to overcome the disease. Collection of stem cells from the bone marrow, their cloning in the laboratory inside the bioreactors-incubators and the subsequent return of the increased number of cells to the patient allow to achieve phenomenal effects on the effect of recovery, which is unattainable by other methods of treatment.
3.Induction of regeneration of organs and tissues — technologies of regenerative medicine.
— Treatment of traumatic injuries of the nail phalanx of the hand in children >>>
The technology of conservative treatment of children aged 1 to 12 years (the period of child postnatal development) with traumatic defects of the fingertips has been developed. On the injured finger, a special isolation chamber is placed, filled with a sterile solution. The method makes it possible to effectively stimulate the regeneration growth of the distal part of the nail phalanx in the conditions of the aquatic environment. It is the newest method of treatment of hand injuries and an example of one of the directions of development of regenerative medicine.
— Restoration of the bones of the cranial vault by induction of organotypic regeneration.
One of the first methods of treatment, which underlies universal methodological approaches to treatment from the position of regenerative medicine. It was created in the middle of the last century by Professor L. V. Polezhaev. If a fragment of the bones of the cranial vault is lost (as a result of an injury), the defect in the course of the reconstruction operation was filled with its own crushed bone tissue (for example, the rib). The wound was sore. Bone sawdust served as a matrix on which the full restoration of the skull took place. Regeneration as a result of such intervention was so perfect that it is subsequently difficult to identify the zone of damage.
— Resuscitation of damaged tissues in aqueous bioreactor chambers.
— Treatment of supercritical burns in a «Regeneratron» type unit.
4.Mutation of Delta 32 and treatment of Acquired Immunodeficiency Syndrome.
The technology arose after the discovery of a rare genetic mutation, called Delta 32. People with this mutation are resistant to the human immunodeficiency virus. Chimerization of the immune system of a patient with AIDS in the transplantation of stem cells from specially selected donor bone marrow from a human donor, whose mutation in the genes has made it resistant to the virus, makes it possible to cure this terrible disease.
5.Cloning of bone marrow stem cells.
The technology of growing cells of the human immune system in the body of the pig’s fruit has been developed. Rarely enough mutations of superstability to viruses and oncological diseases can be expanded (multiplied) outside the human body. Conditions of internal tissue intramembrial environment during chimerization of animal fetuses by human cells allow cloning stem cells with useful properties and solve the problem of insufficient amount of donor cell material (within the adult cell donor organism it is impossible to build up a significant amount of necessary cellular material, which is possible in the organism of rapidly growing animal fetuses). Obtaining such cells with the help of this technology can effectively treat oncological and immunodeficient diseases and act as a basis and an important addition, including a part of the technologies described above.
Despite the different: 1) the mechanisms of action, 2) the provision of the presented technologies, 3) the sections of medicine where it is possible to use them, it is obvious that the same conceptual and terminological arsenal, common approaches and explanations of the mechanisms of action are used, which allows us to state that The development of innovative biomedical technologies is possible only on the basis of a unified approach, based primarily on knowledge in the field of cellular biology and developmental biology.
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